MRI-based quantification of intratumoral heterogeneity for predicting recurrence risk in ER+/HER2- breast cancer.

Authors

Yang Chen, Jie Shi, Jing Chen, Lizhi Xie, Jin Ye, Wei Tang, Qin Xiao, Yan Huang, Yajia Gu, Weijun Peng

Published in

Insights into imaging. Volume 17. Issue 1. Jun 27, 2026. Epub Jun 27, 2026.

Abstract

The need for a cost-effective, rapid, and increasingly accessible alternative to the 21-gene assay prompted this study, which developed a novel MRI-based intratumoral heterogeneity score (ITHscore) to quantify tumor heterogeneity and integrated it with radiomic and clinical features to predict the 21-gene recurrence score (RS).
This retrospective study included ER+/HER2- breast cancer patients who underwent 21-gene assay and preoperative MRI at our institution (April 2017-March 2019). Patients were randomly split into training (70%) and internal test (30%) cohorts, with an external test cohort from the public Duke-Breast-Cancer-MRI dataset. Tumor volumes of interest were automatically segmented using a pre-trained Scalable and Transferable U-Net framework, followed by k-means clustering to compute the ITHscore. Predictive models for the RS were built using clinical, radiomics, and ITHscore features with the support vector machine method, and evaluated by receiver operating characteristic curves.
The institutional dataset comprised 452 patients (training: 316 (187 high-risk, 129 low-risk); internal test: 136 (80 high-risk, 56 low-risk)), while the external Duke cohort included 230 patients (44 high-risk, 186 low-risk). The ITHscore was significantly elevated in high-risk patients (p < 0.001), and its incorporation into the clinical-radiomic model improved RS prediction, yielding AUCs of 0.86 for the internal test cohort and 0.82 for the external test cohort.
In this exploratory study, the ITHscore, which held promise as a noninvasive and intuitive means of characterizing intratumoral heterogeneity, demonstrated a potential incremental value for predicting RS in patients with ER+/HER2- breast cancer.
The MRI-derived quantification of intratumoral heterogeneity facilitates simple and quantitative assessment of tumor heterogeneity and demonstrates potential incremental value in providing a rapid, cost-effective, and accessible prediction of the recurrence score in ER+/HER2- breast cancer.
There is a need for a cost-effective, rapid, and increasingly accessible alternative to the 21-gene assay for predicting recurrence risk in ER+/HER2- breast cancer. The intratumoral heterogeneity score demonstrated potential as a noninvasive, intuitive, and quantitative biomarker for characterizing intratumoral heterogeneity and predicting recurrence score.

PMID:
42365208
Bibliographic data and abstract were imported from PubMed on 28 Jun 2026.

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