Photoinduced Alkene Carbothiolation via Fe/Ni Dual Catalysis.

Authors

Lifang Wang, Ran Xu, Wenlong He, Hui Zi, Fangyi Qu, Ziyi Xu, Shuyang Liu, Yunhe Jin

Published in

Organic letters. Jun 28, 2026. Epub Jun 28, 2026.

Abstract

Alkene carbothiolation enables simultaneous construction of C-C and C-S bonds yet remains challenging for the synthesis of thioethers because low-valent sulfur species readily coordinate to and deactivate transition metal catalysts. Herein, we report a photoinduced Fe/Ni dual-catalytic system that achieves alkene carbothiolation through direct C(sp³)-H activation of simple alkanes. From the merger of ligand-to-metal charge transfer (LMCT)-enabled alkyl radical generation with nickel-catalyzed cross-coupling/sulfide oxidation state modulation, this strategy enables efficient installation of both carbon and sulfur functionalities across alkenes while bypassing the need for prefunctionalized radical precursors. The method provides straightforward access to structurally diverse thioethers from abundant hydrocarbon feedstocks and exhibits broad functional group tolerance and good scalability.

PMID:
42365504
Bibliographic data and abstract were imported from PubMed on 28 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.