In Situ Production of Phosgene: Utilization in Urea Synthesis.

Authors

Dan-Ting Wei, Bin-Xuan Zou, Li-Gang Kou, Qiong Jia, Yong-Qiang Wang

Published in

The Journal of organic chemistry. Jun 28, 2026. Epub Jun 28, 2026.

Abstract

Phosgene, as a crucial chemical, is used to produce polymers, agrochemicals, and pharmaceuticals. Herein, we report a mild iron-catalyzed in situ conversion of CCl₄ to phosgene, applied to the synthesis of various ureas. Using Fe(acac)₃/CCl₄ to replace dangerous phosgene offers significant advantages in terms of its safety and easy operation. Given the broad utility of phosgene and the importance of ureas in drugs and functional materials, this method, as a convenient and adaptable approach, holds promise for academic and industrial applications.

PMID:
42365500
Bibliographic data and abstract were imported from PubMed on 28 Jun 2026.

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