Authors
Xiaoning Li, Yumeng Guo, Xiaonan Wang, Chen Liu, Meijuan Shi, Huirui Zhu, Xiang Zhai, Yuyao Wang, Tao Yang, Hong Zhao, Bingmei Chang, Zhizhen Liu, Wenting Liang, Xiaojing Yang, Baofeng Yu, Tao Gong, Rui Guo
Published in
Biomaterials advances. Volume 188. Pages 215044. Jun 26, 2026. Epub Jun 26, 2026.
Abstract
Ovarian cancer is the gynecological malignancy with the highest mortality rate. Platinum resistance remains a major clinical challenge, severely limiting the therapeutic efficacy of cisplatin-based chemotherapy. In recent years, nanomedicine delivery systems have emerged as a promising strategy to enhance the efficacy of conventional cancer treatments. Herein, we constructed a multifunctional graphene oxide-based nanoplatform by functionalizing graphene oxide with hyaluronic acid, gold nanorods, and indocyanine green, followed by loading of cisplatin to form GO-HA-GNRs-ICG@Pt. This nanoplatform exhibits remarkable photothermal and photodynamic conversion efficiency, active tumor-targeting capability, and pH/near-infrared light dual-responsive cisplatin release. More importantly, in vitro and in vivo studies demonstrate that GO-HA-GNRs-ICG@Pt achieves significantly higher therapeutic efficacy and better biosafety compared to cisplatin monotherapy in A2780 ovarian cancer cells. Mechanistically, we discovered that GO-HA-GNRs-ICG@Pt activates the ROS-PINK1/Parkin-mediated mitophagy signaling axis, ultimately enhancing the cisplatin sensitivity of ovarian cancer cells. This work not only provides a theoretical foundation for the development of targeted multifunctional nanoplatforms for integrated cancer therapy but also offers a new synergistic treatment strategy with potential for addressing drug resistance in clinical ovarian cancer.
PMID:
42365727
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.
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