An Activatable fluorescence probe for real-time monitoring of Peroxynitrite in diabetic wound mouse model.

Authors

Le-Yan Zhou, Qi-Zi Chen, Han Liu, You-Zhen Feng, Zhong-Yuan Cheng, Ru Yan

Published in

Bioorganic chemistry. Volume 180. Pages 110177. Jun 27, 2026. Epub Jun 27, 2026.

Abstract

Diabetic wound (DW) is a severe and disabling complication of diabetes mellitus (DM), generally characterized by delayed healing, persistent inflammation, and insufficient reliable biomarkers for early diagnosis. These clinical limitations emphasize the urgent need for sensitive, non-invasive, and real-time analytical strategies to monitor disease progression. In this study, we developed LRX, an activatable fluorescent molecular probe designed for the selective detection of peroxynitrite (ONOO^-). Systematic evaluations demonstrated that LRX exhibited excellent selectivity toward ONOO^-, high chemical stability, and favorable biocompatibility. By applying this probe in a DW mouse model, dynamic changes in ONOO^- levels were successfully visualized and monitored in vivo. These results indicate that LRX can serve as a sensitive and practical platform for real-time imaging of ONOO^- fluctuations under diabetic pathological conditions. Overall, this work provides new insight into nitro-oxidative stress-related mechanisms involved in diabetic complications and offers a useful molecular imaging tool for future diagnostic and therapeutic studies.

PMID:
42365674
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.