Synthesis and Characterization of Novel Non-Peripheral Phthalocyanines for Efficient Singlet Oxygen Generation: Comparison of Photochemical and Sonophotochemical Methods.

Authors

Fatma Aytan Kılıçarslan, Ceren Can Karanlık, Ali Erdoğmuş

Published in

Journal of fluorescence. Jun 29, 2026. Epub Jun 29, 2026.

Abstract

Recent advancements in sonophotodynamic therapy (SPDT) have highlighted the growing demand for the development of novel and effective sonosensitizers/sonophotosensitizers for cancer treatment. Among the various candidates, phthalocyanines have attracted significant attention due to their highly versatile molecular structures and tunable photophysical and physicochemical properties. In this study, 3-[4-(hexyl benzoate)] substituted metallophthalocyanines were synthesized with peripheral substitution and comprehensively characterized using standard spectroscopic techniques. The singlet oxygen generation efficiencies of the synthesized compounds were systematically evaluated under photochemical and sonophotochemical conditions. The results demonstrate that the newly designed phthalocyanines possess promising potential as efficient sensitizers for both PDT and SPDT applications, offering synergistic enhancement in singlet oxygen production.

PMID:
42366276
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.