A Rare Case Report of Penile Necrosis Successfully Treated With Early Hyperbaric Oxygen Treatment.

Authors

İbrahim Ethem Akın, Mustafa Özay

Published in

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. Volume 53. Issue 2. Pages 291-294.

Abstract

Warfarin is a widely used oral anticoagulant for the treatment of thromboembolic disorders. Warfarin-induced skin necrosis (WISN), a serious but rare complication, typically affects the breasts, hips, and abdomen. Penile necrosis, however, has been reported only in exceptionally rare cases.
In this report, we present the successful outcome of early hyperbaric oxygen treatment (HBO₂) in a patient who developed glans penis necrosis during warfarin treatment and was subsequently diagnosed with protein C deficiency. The patient underwent nine HBO₂ sessions initiated early in the disease course and achieved full recovery without tissue loss.
To our knowledge, this is the first reported case in which HBO₂ was used as part of a combination treatment for penile necrosis in a patient with protein C deficiency. Hyperbaric oxygen treatment may represent an effective therapeutic option in rare cases of warfarin-associated penile necrosis.

PMID:
42365950
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.

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