Authors
Qian Xu, Jie Chen, Yingmeng Li, Yi Zhou, Yang Jin, Liying Zhang, Shuhu Du
Published in
Analytical methods : advancing methods and applications. Jun 29, 2026. Epub Jun 29, 2026.
Abstract
To facilitate the reliable analysis of the inorganic ingredients in Chinese mineral medicine, a validated Raman mapping strategy for assaying aluminum potassium sulfate dodecahydrate (KAl(SO4)2·12H2O) in alumen was reported. In this strategy, the internal standard quantitation and simple pellet methods were introduced to minimize the interference from undesirable backgrounds. The impact of the physical properties (including particle size and compactness) of the as-prepared tablets on Raman signals was also systematically evaluated. Compared with the dramatic signal fluctuation (RSD > 25%) observed in random single-point Raman measurement, the Raman mapping measurement exhibited significantly higher repeatability (RSD < 5%). The entire process can be completed within 30 min. Meanwhile, the spatial visualization distribution of the multiple compounds from the as-prepared tablets was achieved by assigning different colors using Raman mapping with the MATLAB imaging algorithms. Compared with the titration method commonly used in mineral medicine quantification, the validated Raman mapping strategy for non-destructively analyzing KAl(SO4)2·12H2O greatly simplified the complicated operating steps and improved the reproducibility of experiment results. This could provide a new window for inorganic sample analysis, particularly in the quantification of mineral medicine.
PMID:
42366767
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.
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