Copper-Dependent Polysaccharide Monooxygenases: Mechanism and Function.

Authors

Allison E Batka, Michael A Marletta

Published in

Chemical reviews. Jun 29, 2026. Epub Jun 29, 2026.

Abstract

Polysaccharide monooxygenases (PMOs) constitute a superfamily of enzymes that hydroxylate carbon atoms in glycosidic bonds, ultimately leading to the degradation of carbohydrate polymers. PMOs catalyze this challenging transformation at a mononuclear copper site and utilize either O₂ or H₂O₂ as a cosubstrate. In this review, the mechanisms of three types of catalytic chemistry are discussed: monooxygenase (O₂ as a cosubstrate), oxidase (O₂ reduction to H₂O₂), and peroxygenase (H₂O₂ as a cosubstrate). Key discoveries in the understanding of PMO mechanism and function are described. Several important questions remain unanswered about the utilization of O₂ and H₂O₂ as cosubstrates for polysaccharide hydroxylation. This review will summarize the progress toward understanding the mechanism of O₂ activation by this unique class of monooxygenases.

PMID:
42371685
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.