Pitfalls in Bone and Soft Tissue Pathology of the Head and Neck: Primary Intraosseous Rhabdomyosarcoma/FUS::TFCP2-Rearranged Spindle Cell Rhabdomyosarcoma and Transdifferentiated/Dedifferentiated/Undifferentiated Melanoma.

Authors

Omar Habeeb

Published in

Head and neck pathology. Volume 20. Issue 1. Jun 29, 2026. Epub Jun 29, 2026.

Abstract

Because of their relative rarity, bone and soft tissue lesions of the head and neck region can present a diagnostic challenge to anatomic pathologists who practice in a general surgical pathology model-while novel lesions may be unfamiliar to subspecialty head and neck pathologists.
This review focuses on a diagnostically confounding neoplasm that arises in the bone (primary intraosseous rhabdomyosarcoma / FUS::TFCP2-rearranged spindle cell rhabdomyosarcoma) and soft tissue (trans-/de-/undifferentiated melanoma) of the head and neck region-each of which can easily be mistaken for more common entities.
The clinical, radiological, and histopathologic findings (including the molecular pathogenesis) of each neoplasm is discussed-along with selected differential diagnoses.
The accurate recognition of these neoplasms ensures that patients are reviewed, treated, and followed at the appropriate multidisciplinary meeting.

PMID:
42371216
Bibliographic data and abstract were imported from PubMed on 29 Jun 2026.

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