10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the "Ceiling Efficacy Effect" of Modern Antifungals?

Authors

Ariel D Szvalb, Sebastian Wurster, Takahiro Matsuo, Teny M John, Adam G Stewart, Sung-Yeon Cho, Ying Jiang, Dimitrios P Kontoyiannis

Published in

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Jun 29, 2026. Epub Jun 29, 2026.

Abstract

Given competing death causalities among hematological malignancy patients with invasive aspergillosis (IA), we assessed IA-attributable, contributable, and all-cause mortalities in patients with culture-confirmed IA. Although attributable mortality decreased, contributable and all-cause mortalities remained high. Our data suggest that improving survival would require host augmentation, in addition to improved antifungals.

PMID:
42372090
Bibliographic data and abstract were imported from PubMed on 30 Jun 2026.

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