First Total Synthesis of Cryptolaevilactones, Unique Spiromeroterpenoids.

Authors

Tomoya Nishida, Yuta Miura, Yohei Saito, Kyoko Nakagawa-Goto

Published in

The Journal of organic chemistry. Jun 29, 2026. Epub Jun 29, 2026.

Abstract

Cryptolaevilactones (CLs) A-L (1-12), twelve previously isolated spiromeroterpenoids, feature a unique spiro[3.5]nonene skeleton formed from a polyketide chain and a monoterpene. CLs A-C and L (1-4) are diastereomers with different configurations at three chiral centers around a spiro moiety. Herein, we reported the first total syntheses of 1-3 via a convergent strategy accomplished through the construction of three components, a styryl group, a lactone chain, and a spiro ring moiety (isopropylspiro[3.5]nonenone). In this study, the previously unreported compound 13 (CL N) was identified as a natural product from Cryptocarya laevigata.

PMID:
42374022
Bibliographic data and abstract were imported from PubMed on 30 Jun 2026.

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