Visible-Light-Promoted Carbamoylation: Access to Diarylhydrazine Carbonyl Amino Acid/Peptide Derivatives.

Authors

Fan-Lin Zeng, Lan Wang, Yu-Xin Luo, Jinwei Yuan, Bing Yu, Teck-Peng Loh

Published in

Organic letters. Jun 30, 2026. Epub Jun 30, 2026.

Abstract

Integrating amino acids/peptides into hydrazine skeletons remains a significant challenge. We report a visible-light-induced carbamoylation using DHP-tagged amino acids/peptides as radical precursors for the green synthesis of diarylhydrazine carbonyl amino acid/peptide derivatives (37 examples, up to 96% yield). This first integration of amino acid/peptide motifs into hydrazines features mild conditions, external oxidant/additive-free, broad substrate scope and excellent compatibility. It enables late-stage modification of proteins/amine-containing functional molecules, offering a sustainable strategy for peptide modification and drug discovery.

PMID:
42378649
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.

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