Adult Wilms' Tumor during Pregnancy: A Rare and Challenging Clinical Scenario with Literature Review.

Authors

Pushpita Roy, Syed Md Asadul Hoque, Wai Wai Mroy

Published in

Journal of kidney cancer and VHL. Volume 13. Issue 2. Pages 29-37. Epub Jun 15, 2026.

Abstract

Wilms' tumor (nephroblastoma) is a predominantly pediatric malignancy and is exceedingly rare in adults, particularly during pregnancy. We report a case of a 26-year-old South Asian woman diagnosed with a left-sided large retroperitoneal mass incidentally during the second trimester of pregnancy. The patient underwent radical nephrectomy during pregnancy, and histopathology and immunohistochemistry confirmed high-risk nephroblastoma. The patient was closely monitored throughout the pregnancy period and delivered a healthy preterm infant via cesarean section. Systemic chemotherapy was started after the delivery. Despite multimodal management, including surgery and systemic chemotherapy, the disease showed aggressive progression with widespread metastases. The patient required multiple lines of chemotherapy and palliative care, with partial symptomatic improvement. This case highlights the diagnostic and therapeutic challenges of managing adult Wilms' tumors during pregnancy, the importance of multidisciplinary care, and the need for timely intervention to optimize maternal and fetal outcomes.

PMID:
42382642
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.

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