Association between cardiometabolic risk factors cluster and all-cause mortality in type 2 diabetes.

Authors

Qingfang He, Hongting Zhu, Yong Wang, Xiaoyan Zhou, Yuting Han, Ruying Hu

Published in

Journal of diabetes investigation. Jul 01, 2026. Epub Jul 01, 2026.

Abstract

To investigate the association between the cardiometabolic risk factors cluster (CRFC) and all-cause mortality in type 2 diabetes (T2D).
Data from the Zhejiang Rural T2D Cohort (2016-2024) included 10,310 participants. Four cardiometabolic risk factors (CRFs) were evaluated: central obesity, elevated blood pressure, high triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-C). After adjusting for confounders, multivariate Cox regression models were constructed to estimate hazard ratios (HRs). A Total CRFs Score (TCRFS), weighted by regression coefficients of individual CRFs, was stratified into four groups based on quartiles (Participants had a mean age of 63.54 ± 9.77 years, with the most prevalent CRFs being elevated blood pressure (86.97%), followed by elevated TG (41.21%), low HDL-C (38.71%), and central obesity (32.96%). Over a mean 8.12 ± 1.71 years of follow-up, 1,770 deaths occurred (death density: 211.21/10,000 person-years). No single CRF, except for TG, showed a significant association with all-cause mortality, whereas the TCRFS was a significant predictor (HR = 2.719, 95%CI (1.360, 5.437), p = 0.005). Furthermore, participants in the highest TCRFS quartile (≥P75) had a significantly higher mortality risk compared to those in the lowest quartile (CRFC is significantly associated with increased all-cause mortality risk in T2D patients. Early comprehensive assessment and intervention for cardiometabolic risk factors may reduce mortality in this population.

PMID:
42381554
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.

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