Relationships between pre-, post-, and inter-ictal psychiatric symptoms in patients with epilepsy.

Authors

Shingo Yasumoto, Hiromichi Motooka, Yuji Ito, Masaya Mashimoto, Kenta Murotani, Ryota Ogata, Motohiro Ozone

Published in

PCN reports : psychiatry and clinical neurosciences. Volume 5. Issue 3. Pages e70369. Epub Jun 30, 2026.

Abstract

Although pre- and post-ictal psychiatric symptoms (PS) in patients with epilepsy are well known, the prevalences and pathophysiologies remain unclear. We investigated the prevalences and durations of pre- and post-ictal PS, related factors, and associations between pre- and post-ictal PS.
In the Neuropsychiatry Department of Kurume University Hospital, patients with epilepsy were interviewed regarding pre- and post-ictal PS. Multivariate logistic regression analyses were performed on clinical variables and pre- or post-ictal PS. McNemar analyses were performed to clarify differences in the occurrence of pre- and post-ictal PS.
Five percent of patients had only pre-ictal PS, 29% had only post-ictal PS, and 10% had both pre- and post-ictal PS. The most common symptoms were depressive symptoms (25%) and anxiety symptoms (16%) in the post-ictal period, and irritability symptoms (7%) and anxiety symptoms (5%) in the pre-ictal period. The duration of PS was more than 1 day but less than 1 week in many patients. Post-ictal PS showed a substantially higher ratio of a history or comorbidities of inter-ictal psychiatric disorders (IPD). In addition, post-ictal psychotic symptoms and post-ictal irritability symptoms were significantly associated with psychosis in IPD. Furthermore, while the incidence of PS was significantly higher with post-ictal PS alone than with pre-ictal PS, cases with pre-ictal PS had a significantly higher rate of post-ictal PS.
Post-ictal PS appeared relevant to IPD, and pre-ictal PS was associated with the expression of post-ictal PS.

PMID:
42383149
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.

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