Biodegradable Self-Powered Electrotherapy Patch for Integrated Smart Wound Management.

Authors

Wenrui Zhang, Qian Lin, Yicheng Hu, Jiancheng Zhang, Hao Mo, Wencheng Li, Lijun Zhang, Hongnv Yu, Nan Zhu

Published in

Analytical chemistry. Jul 01, 2026. Epub Jul 01, 2026.

Abstract

Smart patches based on multimodal wearable devices enable real-time physiologic monitoring and proactive interventions to promote wound healing. Herein, we describe a biodegradable wearable electrotherapy patch (E-patch) that integrates noninvasive self-powered electrical stimulation (ES) therapy for tissue regeneration and a multiplexed electrochemical biosensor array for continuous monitoring of wound status. Custom-developed supercapacitor arrays (SCs) supply stable energy for ES, and constructed wearable biosensors enable sensitive monitoring of biomarkers in the wound exudate. As-fabricated wearable E-patches degrade harmlessly after operation, significantly reducing the environmental pollution pressure associated with flexible electronics. In vitro studies demonstrated that an applied electric field (EF) significantly promotes cell-directed alignment, which is crucial for tissue regeneration and remodeling. In vivo investigations in the Sprague-Dawley (SD) rat model illustrate that combination therapy dramatically accelerates wound healing. Overall, this work provides a promising strategy toward integrated smart wound management and future feedback-assisted wearable therapeutic systems.

PMID:
42383845
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.

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