mGem: A perfect storm in the era of global warming-the convergence between thermotolerant fungi and altered immunity.

Authors

Frederic Lamoth, Dimitrios P Kontoyiannis

Published in

mBio. Pages e0075026. Jul 01, 2026. Epub Jul 01, 2026.

Abstract

The evidence supporting the impact of global warming on the epidemiology of infectious diseases, including fungal infections, is increasing. Fungi have a remarkable ability to adapt to heat and pollution, and to disseminate via air, water ecosystems, or wildfire smoke. Their genetic plasticity can lead to thermotolerance, the ability to find new ecological niches, and fitness gains. Natural reservoirs of the fungal biomass, which are heavily affected by global warming, may serve as the environments from where new fungal diseases originate, as illustrated by the recent emergence of Candidozyma auris and Rhodosporidiobolus fluvialis. Moreover, global warming also affects human skin/mucosal integrity and local or systemic immune responses, which could increase host susceptibility to fungal infections. This review examines the impact of global warming on the complex fungi-host interactions, which can lead to new challenges in mycology, and discusses possible mitigation strategies.

PMID:
42383752
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.

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