Authors
Lili Wu, Xuru Zhang, Lihua Zhang, Shuaiqing Chen
Published in
The Journal of international medical research. Volume 54. Issue 6. Pages 3000605261464298. Epub Jul 01, 2026.
Abstract
BackgroundThe neutrophil percentage-to-albumin ratio has shown prognostic significance across several chronic diseases; however, its relevance within the context of sleep disorders has not been investigated.MethodsThis study utilized data from the National Health and Nutrition Examination Survey for the years 2005-2014 to explore the connection between the neutrophil percentage-to-albumin ratio and all-cause mortality in people with sleep disorders. Mortality risk was assessed using Cox regression, and the analyses included restricted cubic spline, Kaplan-Meier survival, subgroup, and time-dependent receiver operating characteristic curve analyses.ResultsA positive correlation was identified between the neutrophil percentage-to-albumin ratio and mortality risk among individuals with sleep disorders (hazard ratio = 1.09, 95% confidence interval: 1.05, 1.14). A comparison between the highest (Q4) and lowest (Q1) quartiles revealed that patients in Q4 had an 86% higher mortality risk (hazard ratio = 1.86, 95% confidence interval: 1.31, 2.65). Subgroup analysis further confirmed consistency across different demographic and clinical strata (all p for interaction > 0.05). Furthermore, the neutrophil percentage-to-albumin ratio demonstrated strong predictive performance for early mortality risk in patients with sleep disorders (1-year area under the curve = 0.751, 95% confidence interval: 0.693, 0.808).ConclusionsAmong patients diagnosed with sleep disorders, higher levels of NPAR are independently linked to an elevated risk of all-cause mortality.
PMID:
42383754
Bibliographic data and abstract were imported from PubMed on 01 Jul 2026.
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