Lewy pathology largely absent in prefrontal cortices of Parkinson's disease patients undergoing deep brain stimulation.

Authors

Ariela S Buxbaum Grice, Brian H Kopell, Klaudia F Laborc, Anina N Lund, Renata Gonzalez Chong, Meredith Spadaccia, Gerard Ona, Girish Nadkarni, John F Crary, Alexander W Charney, Noam D Beckmann

Published in

NPJ Parkinson's disease. Volume 12. Issue 1. Jul 01, 2026. Epub Jul 01, 2026.

Abstract

Parkinson's disease (PD) patients undergo deep brain stimulation (DBS) when other treatments are insufficient. Given the patients' advanced clinical stage, an advanced neuropathological stage is assumed. We examined Lewy pathology in prefrontal cortices (PFCs) of DBS recipients. Virtually no Lewy pathology was seen in PD biopsies. In contrast, postmortem PD PFC samples showed significantly greater Lewy pathology than controls. Thus, DBS patients may be less neuropathologically advanced in progression than previously thought.

PMID:
42386762
Bibliographic data and abstract were imported from PubMed on 02 Jul 2026.

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