Authors
Mehmet Gülcan, Pınar Talay Pınar
Published in
Analytical and bioanalytical chemistry. Jul 01, 2026. Epub Jul 01, 2026.
Abstract
In this study, a Ti3C2Tx-MXene-based molecularly imprinted polymer sensor (MX/GCE-MiP) was developed for the electrochemical determination of the tyrosine kinase inhibitor lenvatinib. By combining the high surface area and conductivity of Ti3C2Tx-MXene with the selective recognition properties of molecularly imprinted polymers, a sensitive electrochemical sensing platform was obtained. The analytical performance of the sensor was evaluated by square-wave voltammetry (SWV) using the [Fe(CN)6]-3/-4 redox probe system after rebinding of lenvatinib within the imprinted cavities. Under optimized experimental conditions, the proposed sensor exhibited a linear response in the concentration range of 5.0-30.0 nM with a limit of detection (LOD) of 0.29 nM. Selectivity studies performed in the presence of dopamine, uric acid, ascorbic acid, and futibatinib demonstrated a significantly higher response toward lenvatinib under identical experimental conditions. In addition, the sensor showed good repeatability (3.20%), reproducibility (3.65%), and storage stability (4.1%). The applicability of the proposed sensor was preliminarily evaluated in synthetic serum and urine samples, yielding acceptable recovery values. Overall, the developed MX/GCE-MIP sensor provides a simple, sensitive, and cost-effective platform for the electrochemical detection of lenvatinib.
PMID:
42387095
Bibliographic data and abstract were imported from PubMed on 02 Jul 2026.
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