Limitations of Current Therapies and Barriers in Alzheimer's Disease.

Authors

Ayeshah Hussain, Iffat Alam, Devendra K Agrawal

Published in

Archives of internal medicine research. Volume 9. Issue 2. Pages 136-144. Epub May 27, 2026.

Abstract

Alzheimer's disease (AD) remains a major global health crisis due to its complex pathophysiology and limited therapeutic effectiveness. Despite advances in understanding key mechanisms such as amyloid-beta accumulation, tau pathology and neuroinflammation, current therapies provide limited clinical benefit. Multiple factors contribute to limitations and highlight the difficulty of translating scientific advancements into meaningful improvement in patient outcomes. This article provides a comprehensive and critical review of therapeutic, biological, clinical, and systemic barriers to effective Alzheimer's disease management as well as showcasing emerging strategies aimed to improve early detection, treatment approaches, and overall disease prevention.

PMID:
42389758
Bibliographic data and abstract were imported from PubMed on 02 Jul 2026.

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