Association of estimated pulse wave velocity with non-alcoholic fatty liver disease in multiple cohorts.

Authors

Juan-Juan Ji, Yang Yang, Xin-Yang Zhang, Yan Liu, Fang Yang, Yi-Lei Qiao

Published in

iScience. Volume 29. Issue 7. Pages 116537. Jul 17, 2026. Epub Jun 23, 2026.

Abstract

Diagnosing non-alcoholic fatty liver disease (NAFLD) via ultrasound faces cost and accessibility challenges. We assessed whether estimated pulse wave velocity (ePWV), a measure of arterial stiffness, could serve as an accessible diagnostic marker for NAFLD. In two large cohorts (NAGALA, n = 14,251; NHANES, n = 12,767), higher ePWV independently predicted NAFLD, with top-quartile participants showing significantly higher odds (OR = 1.85, 1.40-2.45 for NAGALA; OR = 3.05, 1.67-5.59 for NHANES). A non-linear relationship was observed: Below the inflection point, each 1 m/s increase in ePWV raised NAFLD risk by 33.6% (NAGALA) and 57% (NHANES), plateauing thereafter. These findings demonstrate that ePWV is independently associated with increased NAFLD risk, supporting its potential utility for early risk stratification.

PMID:
42389608
Bibliographic data and abstract were imported from PubMed on 02 Jul 2026.

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