The impact of the six pillars of lifestyle medicine on the biology of skin aging.

Authors

Jaime Piquero-Casals, Adriana R Cruz, Lucas Ponti-Concetti, Ludmila Prudkin, Anthony Brown, Mónica Foyaca, Eduardo Rozas-Muñoz, Juan Francisco Mir-Bonafé, Daniel Morgado-Carrasco, Thierry Passeron

Published in

Frontiers in aging. Volume 7. Pages 1822471. Epub Jun 17, 2026.

Abstract

Skin aging arises from the interaction between intrinsic genetic programs and cumulative environmental and behavioral exposures collectively defined as the exposome. Increasing evidence indicates that core molecular pathways driving skin aging, including mitochondrial dysfunction, oxidative stress, chronic inflammation, cellular senescence, and extracellular matrix remodeling are responsive to modifiable lifestyle factors. This narrative review examines the mechanistic and translational evidence linking the six pillars of Lifestyle Medicine; nutrition, physical activity, stress regulation, sleep, avoidance of toxic exposures, and social connection, to fundamental biological processes involved in skin aging. Across experimental models and human studies, these lifestyle domains converge on established hallmarks of aging, modulating redox balance, inflammatory signaling, mitochondrial biogenesis, epigenetic regulation, DNA repair, and dermal matrix integrity. Nutritional patterns influence glycation and oxidative stress; physical activity enhances mitochondrial and vascular function; chronic stress and sleep disruption amplify neuroendocrine and inflammatory pathways; toxic exposures activate matrix-degrading and senescence-associated cascades; and social isolation is associated with heightened systemic inflammatory tone. Collectively, these findings support the concept that skin aging represents a biologically plastic process shaped in part by lifestyle-dependent modulation of conserved aging mechanisms. Integrating lifestyle-responsive pathways into skin aging research may enable more targeted, preventive, and mechanism-based strategies in dermatological practice.

PMID:
42389732
Bibliographic data and abstract were imported from PubMed on 02 Jul 2026.

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