Resveratrol in Combination Therapy: Mechanisms and Limitations of Resveratrol in Cancer, Regeneration, and Chronic Disease.

Authors

Effat Noori, Ramazan Rezaei, Samira Valiyari, Mahmood Rekabgardan, Parvin Mohammadi, Fatemeh Soleymani, Elham Sharif, Zohreh Jafari, Delsuz Rezaee, Fatemeh Hajighasemi, Forough Shams

Published in

Iranian biomedical journal. Feb 02, 2026. Epub Feb 02, 2026.

Abstract

Resveratrol (RSV), a nonflavonoid polyphenol phytoalexin, has considerable therapeutic potential for managing chronic and acute diseases due to its anti-inflammatory, anti-cancer, antimicrobial, and antioxidant properties. It can help protect cells from free radical damage and modulate signaling pathways in the body to promote overall health. RSV can also facilitate the therapeutic effects of mesenchymal stem cells by increasing their self-renewal, survival, anti-aging effects, and lineage commitment. However, the natural form of RSV has limitations, such as poor intestinal absorption and low bioavailability. This review focuses on the potential of RSV to explore its effects and mechanisms of action in cancer, regenerative medicine, and chronic disease. It also discusses how RSV can protect normal tissue against genomic instability and presents findings from combination therapies involving RSV and nanoparticle-based agents. Overall, this review highlights the latest developments regarding RSV as a promising compound, emphasizing the potential to overcome its limitations.

PMID:
42391634
Bibliographic data and abstract were imported from PubMed on 03 Jul 2026.

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