[Frontiers in direct compression technology for traditional Chinese medicine powder: integration of excipient modification, particle design, and continuous manufacturing].

Authors

Ge Ao, Tian-Tian Wang, Biao Wu, Xu-Long Liu, Wen-Liu Zhang, Guo-Song Zhang, Jin Su

Published in

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. Volume 51. Issue 8. Pages 2173-2183.

Abstract

Direct compression(DC) technology has been successfully applied in the continuous manufacturing of chemical tablet owing to simplified process and low energy consumption. However, due to its complex composition, poor fluidity, poor compressibility, and strong hygroscopicity, the direct compression of traditional Chinese medicine(TCM) powder faces significant challenges, which seriously restrict the industrialization of this technology and continuous manufacturing mode in the field of TCM. This study focused on the applicability of DC of TCM powder. Furthermore, the latest research progresses in improving the tableting performance through specific strategies such as single excipient modification, functional excipient co-processing development, and particle design(such as the construction of porous particles and composite particles) were systematically reviewed. Additionally, this study discussed the key technologies and compatibility requirements of its integration with the continuous manufacturing process, aiming to provide a practical theoretical basis and technical ideas for promoting the development and application of efficient and stable continuous DC technology of TCM tablet.

PMID:
42392704
Bibliographic data and abstract were imported from PubMed on 03 Jul 2026.

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