Psychiatric comorbidities and treatment patterns in epilepsy: A retrospective review from a tertiary neuropsychiatric clinic.

Authors

Biswa Ranjan Mishra, Debadatta Mohapatra, Santanu Nath, Archana Mishra, Tathagata Biswas, Bishnu Prasad Sahoo, Rituparna Maiti

Published in

Indian journal of psychiatry. Volume 68. Issue 6. Pages 570-574. Epub Jun 20, 2026.

Abstract

Psychiatric conditions, including neurodevelopmental disorders are common among people with epilepsy (PwEs). However, data comparing their distribution across different epilepsy types are limited, particularly in Indian context.
To explore and compare the psychiatric comorbidities and treatment adherence among focal and generalized epilepsy (FE/GE).
This retrospective chart review included 2,258 PwEs attending a tertiary neuropsychiatry clinic in India between 2013 and 2023. Their sociodemographic and clinical data were compared between FE and GE groups.
Nearly 30% had psychiatric comorbidities, most frequently depression (20.6%). Mood and anxiety disorders were more common in FE, while non-affective psychosis was more common in GE. Neurodevelopmental disorders, particularly intellectual disability (ID), were more prevalent in GE (41.9% vs. 16.3%). Medication compliance was suboptimal (60%) and follow-up rates declined over time, reaching 40% at 1-year.
PwEs have a high prevalence of psychiatric comorbidities, with differential occurrences across epilepsy types. Inadequate compliance and follow-up rates remain major challenges.

PMID:
42396429
Bibliographic data and abstract were imported from PubMed on 03 Jul 2026.

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