Ligilactobacillus salivarius Lbs57 Exerted Antibacterial Activity and Modulated Cecal Microbiota to Reduce Foodborne Pathogen Campylobacter jejuni.

Authors

Yifang Cui, Xu Feng, Yuxin Shao, Jiahe Chen, Fangfang Guo, Dongyan Zhang, Fuzhou Xu

Published in

Probiotics and antimicrobial proteins. Jul 03, 2026. Epub Jul 03, 2026.

Abstract

Campylobacter jejuni (C. jejuni) remains a major global foodborne pathogen, with poultry serving as a primary reservoir. This study evaluates the probiotic potential of Ligilactobacillus salivarius Lbs57 against foodborne pathogen C. jejuni. In vitro, the L. salivarius Lbs57 cell-free supernatant (CFS) exhibited broad-spectrum, thermostable antibacterial activity, with the strongest inhibition against C. jejuni. Characterization revealed the activity was pH and protease-sensitive, and resistant to chemical detergents. Multi-omics analysis, including whole-genome sequencing and peptidomics, identified a two-peptide bacteriocin, salivaricin, as the key antimicrobial agent. In chickens, prophylaxis, continuous, and post-colonization interventions significantly reduced C. jejuni cecal colonization, with achieving a 3-log reduction. Furthermore, L. salivarius Lbs57 modulated the cecal microbiota by increasing diversity and enriching beneficial genera (e.g., Bacteroides, Faecalibacterium) while suppressing pathogens like Clostridium and Streptococcus. Overall, these findings highlight the efficacy of L. salivarius Lbs57 is a promising probiotic candidate for limiting C. jejuni and enhancing gut health in poultry.

PMID:
42397539
Bibliographic data and abstract were imported from PubMed on 03 Jul 2026.

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