Therapeutic Vaccines Based on Iron-Coordinated Metal-Phenolic Networks for Eradicating Drug-Resistant Staphylococcus aureus.

Authors

Hao Sun, Suke Liu, Yijun Gu, Liling Xie, Mingchun Li, Qilin Yu

Published in

ACS applied bio materials. Jul 03, 2026. Epub Jul 03, 2026.

Abstract

Drug-resistant Staphylococcus aureus (DRSA) infections present a formidable therapeutic challenge severely threatening human health. To address this, we engineered a metal-phenolic network (MPN) platform that co-immobilizes whole-cell DRSA with immunostimulatory metal ions (i.e., Fe³⁺, Mn²⁺, Zn²⁺) under mild conditions. Among these, the iron-coordinated MPN (SA@FeMPN) exhibited superior potency, leveraging a dynamic valence transition mechanism to robustly amplify the TLR2/NF-κB signaling. This mechanism promoted functional polarization of macrophages to the M1 state and drove dendritic cell maturation. In a murine systemic infection model, SA@FeMPN elicited robust cellular and humoral immunity, achieving a 2-18-fold greater reduction in bacterial burden across major organs compared to other MPNs, and established durable immunological memory to prevent infection relapse. Collectively, this work establishes iron-coordinated MPNs as a rational design platform for next-generation immunotherapy and identifies SA@FeMPN as a promising therapeutic vaccine candidate that not only eradicates established DRSA infections but also confers lasting protection against recurrence.

PMID:
42397939
Bibliographic data and abstract were imported from PubMed on 04 Jul 2026.

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