Authors
Tianyi Chen, Gandong Zhou, Lihao Guo, Ruiyan Zhang, Miaomiao Yuan, Xiaoxiang Yan
Published in
ACS sensors. Jul 03, 2026. Epub Jul 03, 2026.
Abstract
Heart failure (HF) represents the terminal clinical stage of a broad spectrum of cardiac disorders, distinguished by notably high rates of incidence and mortality. Extensive clinical investigations have proved that monitoring of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels can reliably forecast HF and inform targeted clinical decision-making. Current detections for NT-proBNP depend on centralized laboratory instrumentation, which frequently creates delays that hinder the delivery of timely clinical care and decision-making. Here, we present a wearable microneedle-based electrochemical aptamer sensor (MEAS) for real-time, dynamic monitoring detection of NT-proBNP. Furthermore, this MEAS integrates real-time signal processing with wireless communication capabilities (e.g., Bluetooth to smartphones), enabling dynamic data analysis and visual reading out of the NT-proBNP level. In vitro characterization demonstrated high analytical performance, including a wide linear range (10-2000 pg/mL), a low detection limit (8.61 pg/mL), excellent selectivity against common interferents, and stable responses over repeated measurements. The microneedle biosensor exhibited favorable biosafety and enabled reliable in vivo NT-proBNP monitoring, with good agreement between sensor readouts and ELISA measurements. Together, these results position the proposed microneedle aptasensor as a promising alternative to conventional blood-based testing, with the potential to support real-time, patient-centered monitoring and advance next-generation HF management strategies.
PMID:
42397720
Bibliographic data and abstract were imported from PubMed on 04 Jul 2026.
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