Electro-Mediated Regioselective C2-Alkylation of N-Oxide Heteroarenes.

Authors

Komi Djimabi, Sylvain Oudeyer, Jean-François Brière, Vincent Levacher, Hélène Beucher

Published in

Organic letters. Jul 03, 2026. Epub Jul 03, 2026.

Abstract

An electrochemical Minisci-type reaction for the regioselective C2-alkylation of N-oxide heteroarenes is reported herein. N-Hydroxyphtalimide redox-active esters were used as primary, secondary, and tertiary alkyl radical precursors. A variety of 2-alkylheterocyclic N-oxides were prepared in the absence of catalyst and exogeneous oxidant. Preliminary mechanistic studies suggested a radical addition pathway via sequential paired electrolysis.

PMID:
42398031
Bibliographic data and abstract were imported from PubMed on 04 Jul 2026.

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