A new alkaloid isolated from Portulaca oleracea L. and its anti-inflammatory mechanism.

Authors

Pengyan Liu, Jing Liu, Yingdai Zhao, Xixiang Ying, Zheming Ying, Yanling Ren

Published in

Natural product research. Pages 1-5. Jul 03, 2026. Epub Jul 03, 2026.

Abstract

A alkaloid identified as 8-(2-hydroxyethyl)-3,8-diazabicyclo[4.2.0]octa-1,4,6-triene-2-carbaldehyde named Oleradiazahyde was isolated. Its skeleton was assigned by UV, IR, NMR, as well as UHPLC-ESI-Q-TOF/MS. Simultaneously, LPS-activated RAW 264.7 tests revealed that 15 μM compound suppressed NO/IL-6, and 5 μM restrained IL-1β secretion. At 15 μM, oleradiazahyde greatly reduced iNOS protein as well as iNOS and COX-2 mRNA. This compound also restrained COX-2 protein production when administered at 5 μM.

PMID:
42398041
Bibliographic data and abstract were imported from PubMed on 04 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.