Authors
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet
Published in
Molecular oncology. Jul 04, 2026. Epub Jul 04, 2026.
Abstract
Brain tumors remain among the most lethal cancers, largely due to their remarkable heterogeneity, plasticity, and resistance to therapy. The second Brain Tumor Meeting by the Sea (Saint-Malo, France, 2026) brought together researchers, clinicians, and patient representatives to discuss emerging concepts shaping the future of neuro-oncology. A recurring theme was the shift from a tumor-centric perspective toward an ecosystem-based view that integrates tumor cells, microenvironmental cues, developmental context, and patient-centered dimensions. Advances in patient-derived models, multi-omics approaches, spatial technologies, and artificial intelligence are refining tumor classification and revealing novel therapeutic vulnerabilities. Discussions highlighted cellular plasticity and stress-adaptation mechanisms as key drivers of tumor evolution and treatment resistance. They also emphasized the need for identifying dynamic biomarkers and developing more physiologically relevant disease models. Beyond biological discoveries, the meeting underscored the importance of strengthening interactions among research, clinical care, and patient communities. Together, these advances support a more integrated framework for understanding brain tumors and developing future therapeutic strategies.
PMID:
42400318
Bibliographic data and abstract were imported from PubMed on 04 Jul 2026.
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