Estrobolome and the Endocrine-Microbiome Axis in Breast and Endometrial Carcinogenesis.

Authors

Amr Ali Mohamed Abdelgawwad El-Sehrawy, Husni Farah, Firdavs Oripov, Gulnora Shakhmurova, Fatima Mohammed Hussein, Laxmidhar Maharana, Ritesh Singh, Navin Kumar Tailor

Published in

Critical reviews in oncology/hematology. Pages 105471. Jul 04, 2026. Epub Jul 04, 2026.

Abstract

The estrobolome, the community of gut microbial genes involved in estrogen metabolism, may influence hormone bioavailability and cancer risk, although human evidence remains largely associative. This review summarizes evidence that bacterial β-glucuronidases, sulfatases, and hydroxysteroid dehydrogenases regulate enterohepatic estrogen recycling, while microbial metabolism also shapes receptor signaling, genotoxic estrogen metabolites, inflammation, and immune responses. Observational studies link gut microbial composition and function with breast and endometrial cancer, but causality remains unproven. Early dietary, probiotic, antibiotic, and fecal microbiota transplantation studies show biological effects, yet they are not sufficient for clinical application. We propose a functional framework that prioritizes microbial enzymatic activity over taxonomy and highlight multiparametric biomarkers and selective β-glucuronidase inhibition as promising research directions for prevention and adjunct therapy in hormone-driven cancers.

PMID:
42401355
Bibliographic data and abstract were imported from PubMed on 05 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.