Authors
Jack Lam, Raúl Rodriguez-Cruces, Thaera Arafat, Jessica Royer, Judy Chen, Arielle Dascal, Ella Sahlas, Raluca Pana, Robert Hopewell, Chris Hung-Hsin Hsiao, Gassan Massarweh, Jean-Paul Soucy, Pedro Rosa-Neto, Sylvia Villeneuve, Lorenzo Caciagli, Matthias Koepp, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt
Published in
Scientific data. Jul 04, 2026. Epub Jul 04, 2026.
Abstract
Tauopathies are pathologies wherein phosphorylated insoluble tau aggregates in neurons, leading to dysfunction and degeneration. Positron emission tomography (PET) enables measurement of in vivo tau, with second-generation radiotracers such as [18F]MK6240 showing high tau affinity with minimal off-target binding. While tauopathies are commonly linked to age-related neurodegenerative diseases, notably Alzheimer's disease (AD), evidence suggests pathophysiological cascades may begin long before clinical onset. Increasingly, tau is recognized in pathologies affecting younger individuals, including autosomal dominant AD, Niemann-Pick disease type C, chronic traumatic encephalopathy, and epilepsy, thus highlighting the importance of normative data in non-geriatric populations. Here, we present a dataset of 33 young to middle-age healthy adults (mean age 34.0 ± 10.4 years, 12 female) with [18F]MK6240 PET data and T1w magnetic resonance imaging. Longitudinal data are also available in a subset of 9 participants with a minimum follow-up time of 1 year. Our dataset aims to support imaging biomarker studies on younger individuals potentially at risk for AD and to advance work in tauopathies affecting non-geriatric populations generally excluded from neurodegeneration studies.
PMID:
42401601
Bibliographic data and abstract were imported from PubMed on 05 Jul 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 2
- Comments 0