Authors
Shimaa A Atty, Naira A Farid, Nadia F Youssef, Hisham E Abdellatef, Yasmine A Sharaf
Published in
BMC chemistry. Jul 04, 2026. Epub Jul 04, 2026.
Abstract
A sensitive, simple, and environmentally friendly electrochemical voltammetric approach has been developed for the determination of Mirabegron (MRG) in drug substances, drug products, and spiked human plasma samples. For the first time, MRG was measured using a combination of electrochemistry and nanotechnology. A Multiwalled carbon nanotubes/sugar polymer/ zinc oxide nanoparticles carbon paste electrode (MWCNT/ZnO NPs/PS/CPE) was fabricated and used to study the electrochemical behavior of MRG showing a good anodic response in Britton-Robinson buffer (B-R buffer) pH 3.0 utilizing cyclic (CV) and square wave voltammetry (SWV). Linear relationships were recorded between the peak current (Ip ) and MRG concentration ranges of 0.2 × 10- 9 - 100 × 10- 6 M in bulk with correlation 0.9990 and 0.30 × 10- 9 - 100 × 10- 9 M in plasma with correlation of 0.9993. Method sensitivity was demonstrated by the calculation of the detection and quantification limits, which were found to be 6 × 10- 12 M and 19 × 10- 12 M, respectively. Method validation has been evaluated as per ICH guidelines. The acquired results were statistically compared with those of the reported one profitably. Method greenness was evaluated by ECO scale, the Modified Green Analytical procedure index (MOGAPI) and Analytical Greenness Metric Approach (AGREE). The results indicate an excellent green profile, so the developed new voltametric method will be dedicated to the quality control laboratories to contribute to MRG analysis.
PMID:
42401918
Bibliographic data and abstract were imported from PubMed on 05 Jul 2026.
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