Se-enriched yeast improves meat quality through glycerophospholipid metabolism in finishing pigs: insights from a multi-omics analysis.

Authors

Xiangqi Qiu, Panpan Lu, Mingfei Xiao, Sumei Zeng, Li Li, Haitao Yu, Aihua Deng, Min Zhu, E Xu, Xiangfang Zeng

Published in

Journal of animal science and biotechnology. Volume 17. Issue 1. Jul 05, 2026. Epub Jul 05, 2026.

Abstract

The improvement of meat quality by selenium (Se) supplementation has been well documented; however, the effects and underlying mechanisms by which Se-enriched yeast modulates meat quality remain unclear. This study aimed to investigate the effects of Se-enriched yeast on meat quality and its molecular characteristics in finishing pigs. All pigs were fed a Se-deficient diet (SeD) or the same diet supplemented with 0.3, 1, 3, or 5 mg Se/kg (CT, SY1, SY3, and SY5).
Compared with SeD, Se-enriched yeast supplementation, especially SY3, improved marbling score, intramuscular fat content, antioxidant capacity, and fatty acid composition in the LD muscle (P < 0.05). Lipidomic analysis revealed that Se-enriched yeast supplementation altered the abundances of multiple lipid species, while transcriptomic analysis showed significant enrichment of pathways related to unsaturated fatty acid and glycerophospholipid metabolism (P < 0.05). Integrated analyses further identified glycerophospholipid metabolism as a key pathway associated with major lipids, including phosphatidylcholine (PC) and phosphatidylethanolamine (PE), along with regulatory genes glycerol-3-phosphate acyltransferase 3 (GPAT3) and phosphatidylserine decarboxylase (PISD). Correlation analysis indicated that stearoyl-CoA desaturase (SCD), elongation of very long chain fatty acids protein 4 (ELOVL4), and GPAT3 play crucial roles in lipid synthesis.
Se-enriched yeast supplementation at 3 mg/kg improved meat quality, primarily through the regulation of glycerophospholipid metabolism, enhancement of membrane stability, and lipid homeostasis. These findings offer mechanistic insights into the role of Se-enriched yeast and highlight its potential as an effective feed additive for improving meat quality in finishing pigs.

PMID:
42401907
Bibliographic data and abstract were imported from PubMed on 05 Jul 2026.

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