Ligand Redox Reactivity Supports C-F Activation at Al(III).

Authors

Shuyu Xu, Keyan Li, Nathan Phan, James C Fettinger, Louise A Berben

Published in

Inorganic chemistry. Jul 04, 2026. Epub Jul 04, 2026.

Abstract

C-F bond activation has applications in organic synthesis, and known pathways include two- or one-electron reduction of the C-F bond, and fluoride abstraction. Low-valent aluminum(I) complexes are known to activate C-F bonds via an oxidative addition mechanism. Here, we report a stoichiometric activation of C-F bonds in aryl-CF₃ compounds using an Al(III) complex that is supported by a two-electron redox change on the supporting noninnocent ligand. The overall reaction observed involves a two-electron ligand-based oxidation along with the formation of two Al-F bonds to afford [(^PhI₂P⁰)AlF₂]⁺ from (^PhI₂P^2-)AlI, where ^PhI₂P is a diiminepyridine ligand. Possible intermediates including a radical species (^PhI₂P^-)AlF₂ and a fully oxidized [(^PhI₂P⁰)AlI₂]⁺ were synthesized and characterized to better understand the relationship between ligand redox chemistry and C-F bond activation.

PMID:
42400520
Bibliographic data and abstract were imported from PubMed on 05 Jul 2026.

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