Mitochondria produce lactate to vent redox pressure.

Authors

Serwah A Danquah, Lucas B Sullivan

Published in

Trends in endocrinology and metabolism: TEM. Jul 04, 2026. Epub Jul 04, 2026.

Abstract

Conventionally viewed as a waste product or a cytosolic pyruvate source, recent findings suggest that lactate may also directly contribute to mitochondrial oxidative metabolism. Using an intramitochondrial lactate biosensor, Rauseo et al. instead find that energized mitochondria are producers of lactate, which buffers mitochondrial redox to mitigate reactive oxygen species production.

PMID:
42401524
Bibliographic data and abstract were imported from PubMed on 05 Jul 2026.

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