Sustainable water-based green extraction of momilactones A and B from rice husk with enhanced cytotoxic and antibacterial activities.

Authors

Nguyen Thi Doan, Nguyen Van Quan, Nguyen Phuong Mai, Nguyen Dang Duc, Tran Dang Xuan

Published in

Natural product research. Pages 1-8. Jul 05, 2026. Epub Jul 05, 2026.

Abstract

Momilactones A (MA) and B (MB) are bioactive diterpenoid lactones found in rice husk; however, conventional extraction relies on solvent-intensive methanolic methods and exhibits limited efficiency, raising environmental sustainability concerns. This study evaluates water-based green extraction approaches to improve the yields and biological performance of momilactone-enriched extracts while reducing solvent consumption. Freezing (FRH), sonication (SRH), combined freezing-sonication (PFS), and cellulase-assisted extraction (E) were compared with conventional methanolic extraction (MRH) as a control. Freezing at -20 °C for 16 h (FRH2) and sonication for 2 h (SRH1) achieved the highest enrichment of MA (51.9 and 52.7 µg/g, respectively) and MB (32.5 and 34.3 µg/g, respectively), representing 1.2-1.4-fold increases over MRH. These extracts exhibited enhanced cytotoxicity against K562, U937, and THP-1 cell lines (IC₅₀: 80.36-124.76 µg/mL) and antibacterial activity against Staphylococcus aureus (MIC: 2 mg/mL). Overall, water-based physical pre-treatments offer a sustainable platform for momilactone extraction in functional food and pharmaceutical applications.

PMID:
42402179
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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