Chaetochromone A, a 6/6/5 tricyclic chromone derivative from an endophytic fungus Chaetomium sp. SG-01.

Authors

Ting Zhou, Ruihua Mao, Ying Gao, Yinhui Zhou, Xiaokun Yu, Chunlun Qin, Hanli Ruan

Published in

Natural product research. Pages 1-6. Jul 05, 2026. Epub Jul 05, 2026.

Abstract

Chaetochromone A (1), a novel 6/6/5 tricyclic chromone derivative, along with two known naphtho-γ-pyrones, chaetochromins A and B (2 - 3), was isolated from the fermentation of Chaetomium sp. SG-01, an endophytic fungus obtained from the fibrous roots of Schisandra glaucescens Diels. The structures of these compounds, including their absolute configurations, were elucidated by comprehensive analyses of their 1D and 2D NMR, HRESIMS, and single-crystal X-ray crystallography. Compound 1 features a chromone core fused to a five-membered lactone at C-8 and C-12, forming a unique 6/6/5 fused tricyclic ring system. Biological evaluation indicated that compound 1 was inactive in both immunosuppressive and cytotoxicity assays, including concanavalin A (ConA)-stimulated T cell and lipopolysaccharide (LPS)-stimulated B cell proliferation, as well as against three human cancer cell lines (HCT116, MCF-7, and HT-29).

PMID:
42402175
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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