AID and MUM1 Negativity Identifies a Prognostically Favorable Subgroup of Diffuse Large B-Cell Lymphoma/High-Grade B-Cell Lymphoma With Double-Hit MYC and BCL2 or BCL6 and Triple Hit.

Authors

Masashi Miyaoka, Joaquim Carreras, Yara Yukie Kikuti, Haruka Ikoma, Shunsuke Nagase, Atsushi Ito, Makoto Orita, Yuki Tanigaki, Yohei Masugi, Giovanna Roncador, Naoya Nakamura

Published in

Pathology international. Volume 76. Issue 7. Pages e70145.

Abstract

Immunohistochemical negativity of AID and MUM1 identifies a prognostically favorable subgroup of diffuse large B-cell lymphoma/high-grade B-cell lymphoma with double-hit MYC and BCL2 or BCL6 and triple hit, and a gene set and enrichment analysis showed that genes belonged to PI3K-Akt, matrix remodeling and metastasis, cell adhesion and migration, myeloid compartment, and metabolic stress were up-regulated in the AID-negative/MUM1-negative subgroup.

PMID:
42402152
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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