Authors
Aditi Roy, Asavari Raut, Aman Chaudhary, Sayantika Mandal, Dev Dangi, Karan Sewani, Asma Pathan, Mayur Shinde
Published in
Journal of psychosocial oncology. Pages 1-16. Jul 05, 2026. Epub Jul 05, 2026.
Abstract
This study examined psychological distress and financial toxicity among cancer patient-caregiver dyads receiving chemotherapy in Western India, focusing on emotional and financial interdependence.
In this cross-sectional study of 357 chemotherapy patient-caregiver dyads, psychological distress (NCCN Distress Thermometer), financial toxicity (COST-FACIT), and adverse drug reactions (standard causality and severity scales) were assessed, with patient predictors analyzed by multivariable logistic regression and dyadic effects examined using the Actor-Partner Interdependence Model.
Clinically significant distress was reported by 55.74% of patients and 10.92% of caregivers, while nearly 70% of both groups experienced mild-to-moderate financial toxicity. Patient distress was significantly associated with adverse drug reactions (AOR = 2.208), higher patient financial toxicity (AOR = 0.895), caregiver financial toxicity (AOR = 1.056), and caregiver distress (AOR = 1.951). Caregiver distress was significantly associated with caregiver financial toxicity (AOR = 1.19), patient distress (AOR = 0.72), breadwinner status, and marital status. APIM showed strong actor effects for patients (β = 0.446) and caregivers (β = 0.366), and partner effects indicating cross-dyad influence (β = 0.157; β = 0.168).
Psychological distress and financial toxicity are prevalent, and addressing patient-caregiver interdependence-particularly in primary caregivers and patients with treatment toxicities-may improve outcomes.
PMID:
42402196
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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