Concise total synthesis of coerulescine by Cu(I)-catalyzed tandem reaction.

Authors

Bo-Qin Zi, Qiu-Ting Yang, Tian-Feng Peng, Tao Lv, Yu-Xiang Zhao, Xian-Fu Shen

Published in

Journal of Asian natural products research. Pages 1-9. Jul 05, 2026. Epub Jul 05, 2026.

Abstract

Herein, we disclosed a concise total synthesis of indole alkaloid coerulescine via a novel copper(I)-catalyzed tandem reaction of chiral tert-butanesulfinyl amide o-iodoanilide derivative with methyl chloroformate as the electrophile reagent to afford the quaternary carbon stereocenter efficiently, followed by hydrolysis of the tert-butanesulfinyl group and a tandem ammonolysis process to give the key spiro[pyrrolidine-3,3'-oxindole] core of the coerulescine alkaloids.

PMID:
42402193
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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