Effectiveness of polycaprolactone-based dermal fillers for full-face rejuvenation.

Authors

Mírian Cristina Gomes, Marilia de Oliveira Coelho Dutra Leal, Sarah Teixeira Costa, Daniela Veloso Santos Sousa, Tarley Eloy Pessoa de Barros, Cláudio Roberto Pacheco Jodas

Published in

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology. Pages 1-6. Jul 05, 2026. Epub Jul 05, 2026.

Abstract

Aging impacts all facial layers, leading to aesthetic concerns such as lines, folds, and furrows. Injectable dermal fillers are commonly employed to address these changes, with polycaprolactone (PCL) emerging as a widely used and innovative option. Images from before and after PCL injection were analyzed from 31 medical records (n = 31). The treatment points were 11. Images were processed in GIMP, and the selection of the facial area was in Adobe Photoshop, and the selected area was calculated in ImageJ. Associations between measurement variations before and after the procedure were tested concerning the increase and decrease in projections and shadows in the places where PCL was injected. The margin of error was 5% (p = .05) in the Bootstrap test (n = 300), Tukey's post hoc test, and ANOVA. There was no statistically significant difference in the zygomatic (p = .093), angle and ramus of the mandible (p = .07), and labiomental sulcus (p = .3559). In all other areas, there was a reduction in the shadow area, which was associated with an increase in the projection/prominence of the regions adjacent to the injection. PCL proved effective in full-face use in most areas tested (eight out of 11): Mean percentage reductions were: infraorbital margin (-8.3%, p = .021), palpebromalar groove (-7.4%, p = .006), piriformis fossa (-11.9%, p = .000), nasolabial fold (-9.5%, p = .002), oral commissure (-5.5%, p = .002), mentolabial groove (-9.0%, p = .001), pre-jowl area (-6.9%, p = .001), and chin (-6.9%, p = .001).

PMID:
42402150
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.