Authors
Yuhong Chen, Han Wang, Zhenyu Wang, Yunyu Xie, Funeng Xu, Xiaoxia Liang
Published in
Veterinary and comparative oncology. Jul 06, 2026. Epub Jul 06, 2026.
Abstract
Triple negative breast cancer (TNBC) presents a significant challenge in breast cancer treatment. Canine mammary carcinoma, characterized by spontaneous tumours in female dogs, serves as a robust spontaneous model for TNBC. In this study, DPIA, a potent antitumor agent, was encapsulated into synthesized mPEG-PCL (mPP) to form nano-micelles, aiming to enhance its in vivo therapeutic efficacy. DPIA@mPP exhibited more uniform dispersion and a spheroid-like architecture, with a drug loading rate of 4.31% and an encapsulation rate of 13.10%. Both DPIA@mPP and free DPIA exhibited comparable and significant cytotoxicity against canine mammary carcinoma cells (CMT-7364) in vitro. Encapsulation into mPP enhanced DPIA uptake by CMT-7364 cells, increasing tumour inhibition from 30.31% to 48.55%, while markedly reducing in vivo toxicity. Overall, the DPIA@mPP group demonstrated superior in vivo antitumor efficacy and a good safety profile. Furthermore, preliminary mechanistic studies suggest that DPIA@mPP may promote apoptosis in CMT-7364 cells, potentially through the inhibition of the PI3K/AKT signalling pathway, offering novel insights into TNBC treatment strategies.
PMID:
42405426
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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