Authors
Meng-Jiao Li, Wei Zhao, Cai-Yang Li, Yan-Ling Li, Shi-Hui Ren, Jia-Jia Li, Ling Qiu, Cheng-Wei Yang, Fang-Yi Fan, Hao Yao
Published in
Frontiers in cell and developmental biology. Volume 14. Pages 1862138. Epub Jun 19, 2026.
Abstract
Mesenchymal stem cells (MSCs) have emerged as promising therapeutic candidates for a wide range of intrahepatic and extrahepatic biliary diseases. However, their clinical application remains limited by an incomplete understanding of underlying mechanisms and heterogeneous therapeutic outcomes. This review provides a comprehensive overview of recent advances in MSC-based therapies for biliary system diseases, including primary biliary cholangitis, intrahepatic biliary fibrosis and cirrhosis, biliary atresia, primary sclerosing cholangitis, and cholangiocarcinoma. We summarize both preclinical and clinical evidence and focus on key therapeutic mechanisms, including immunomodulation, antifibrotic activity, regulation of bile acid metabolism, and protection of biliary epithelial cells.
PMID:
42405332
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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