Authors
Maged S Al-Fakeh, Maryam Aldoghaim, Munirah S Alazmi, Yassine El-Ghoul, Ahmed B M Ibrahim
Published in
International journal of biomaterials. Volume 2026. Pages 3245959. Epub Jul 03, 2026.
Abstract
This study focuses on the preparation and properties of nanosized Fe(III) and Cr(III) coordination polymers using cross-linked sodium alginate (AG) and polyacrylic acid (PAA) as biopolymer matrices. The cross-linked ligand biopolymer was prepared, and its reactions with iron(III) chloride and chromium(III) chloride were performed. The obtained complexes were characterized using techniques, including elemental analysis, FT-IR, and UV-Vis. spectroscopy, XRD, and SEM, which confirmed structural integrity, electronic transitions, and unique morphologies of them. The crystallite size of all nanostructured coordination polymers was in the range of 35-40 nm. Thermal analysis (thermogravimetry, derivative thermogravimetry, and differential thermal studies) has been used to study the thermal decomposition stages. All the synthesized coordination polymers were nonelectrolytes with magnetic moments ranging from 3.91 to 5.92 BM. The antimicrobial and antioxidant capabilities of the nanosized metal coordination polymers confirmed their potential to mitigate oxidative stress and related disorders and revealed excellent biocompatibility of the polymeric complexes. Furthermore, preliminary anticancer studies indicated that these Fe(III) and Cr(III) nanosized coordination polymers exhibit significant cytotoxic effects against breast MCF-7 cancer cell lines and no toxicity against normal cell lines, suggesting their potential as drug delivery systems or therapeutic agents.
PMID:
42405305
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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