Authors
Evgenia Tziava, Aikaterini Leventi, Maria Arnaouti, Nektarios Ntalakos, Maria Igoumenidi, Dimitris P Korkolis
Published in
ACG case reports journal. Volume 13. Issue 7. Pages e02229. Epub Jul 03, 2026.
Abstract
Primary hepatic histiocytic sarcoma (HS) is an exceptionally rare malignancy with nonspecific clinical and morphological features that often mimic other high-grade liver tumors making their diagnosis challenging. We report a 74-year-old man presenting with abdominal and back pain, fatigue, and a solitary right-lobe hepatic mass. Imaging suggested hepatocellular carcinoma, and the patient underwent right posterior sectionectomy. Histopathology revealed a high-grade neoplasm of discohesive large cells with eosinophilic cytoplasm and extensive necrosis. Immunohistochemistry confirmed HS. Given the extreme rarity of primary hepatic HS, we provide a focused literature review highlighting diagnostic challenges, immunophenotypic features, and current insights into the molecular landscape of this aggressive neoplasm.
PMID:
42405293
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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