Authors
Yani Wei, Wei Lou, Zongbo Han, Fan Yang, Fengling Li, Haofeng Li, Huijuan Shi, Bing Wei, Hongjun Li, Yuanyuan Zhao, Xiuli Xiao, Yongquan Yang, Anjia Han, Jianhua Yao, Hong Bu
Published in
MedComm. Volume 7. Issue 7. Pages e70826. Epub Jul 02, 2026.
Abstract
Accurate outcome prediction is essential for personalized therapy in patients with breast cancer receiving neoadjuvant therapy (NAT). In this study, we developed and validated a multimodal artificial intelligence model, the ClinicHistomics Integrated Outcome Prediction Model (CIOPM), to predict prognosis in NAT-treated breast cancer patients by integrating clinicopathological data and hematoxylin and eosin (H&E)-stained surgical specimen whole-slide images (WSIs). A total of 847 WSIs from 835 patients across four multicenter cohorts collected between January 2008 and May 2020 were enrolled in model development and external validation. The CIOPM demonstrated robust predictive performance for overall survival (OS) and disease-free survival (DFS) in the two validation cohorts (VCs), yielding C-indices of 0.933 (95% CI: 0.878-0.977) and 0.915 (95% CI: 0.850-0.960) for OS in VC 1, and 0.947 (95% CI: 0.895-0.983) and 0.937 (95% CI: 0.905-0.965) for DFS in VC 2, respectively. The CIOPM enables accurate stratification of patients with NAT-treated breast cancer into high- and low-risk groups, achieving an AUC of 0.957 for both OS and DFS prediction. Moreover, it demonstrated superior performance in ablation studies, subgroup analyses, and clinical risk model comparisons. This model provides reliable risk stratification and personalized treatment decisions.
PMID:
42404588
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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